Antidiabetic, hematoprotective and nephroprotective effects of the aqueous extract of Falcaria vulgaris in diabetic male mice

Mohammad Mahdi Zangeneh, Akram Zangeneh, Reza Tahvilian, Rohallah Moradi

Abstract


Paper description:

  • The antidiabetic effects of Falcaria vulgaris aqueous extract collected in Iran has not been evaluated.
  • We examined the hematological and renal changes of this extract in streptozotocin-induced diabetic mice by stereology. Our findings show that the aqueous extract of F. vulgaris produces favorable antidiabetic, hematoprotective and nephroprotective effects.
  • The obtained results recommend examination of the extract in clinical studies on advancing medical therapy of diabetes mellitus.

Abstract: Falcaria vulgaris has been used in medicine as an antimicrobial agent. The aims of this study were to evaluate the hypoglycemic and nephroprotective activities of the aqueous extract of F. vulgaris in diabetic mice. Diabetes was experimentally induced by intraperitoneal injection of streptozotocin (STZ). The mice were divided randomly into 6 groups as follows: nondiabetic, untreated diabetic, a group that received orally 0.5 mg/kg glibenclamide, and three groups that were given orally 200, 600 and 1800 µg/kg of F. vulgaris, respectively, for 20 days. On the 20th day, the mice were dissected, and blood and kidney samples were collected for analysis of hematological, biochemical and stereological parameters. F. vulgaris at all doses, particularly 1800 µg/kg, significantly (p≤0.05) reduced the levels of urea, creatinine, WBC, eosinophils, basophiles, platelet and increased RBC, Hb, PCV, MCV, MCH, MCHC, lymphocytes and monocytes that were raised after diabetes induction, compared to the untreated diabetic group. Multiple doses of F. vulgaris, particularly1800 µg/kg, significantly (p≤0.05) decreased the total volumes of the kidney cortex, medulla, vessels and renal tubules, as well as the lengths of the vessels and renal tubules, compared to the untreated diabetic group. Also, F. vulgaris at all doses significantly prevented glomerular hypertrophy and reduction of glomeruli numbers in comparison with the untreated diabetic group. In conclusion, F. vulgaris possesses antidiabetic, hematoprotective and nephroprotective properties and can improve renal structural and blood biomarkers in STZ-induced nephrotoxicity in mice.

https://doi.org/10.2298/ABS180222027Z

Received: February 22, 2018; Revised: June 11, 2018; Accepted: June 11, 2018; Published online: June 15, 2018

How to cite this article: Zangeneh MM, Zangeneh A, Tahvilian R, Moradi R. Antidiabetic, hematoprotective and nephroprotective effects of the aqueous extract of Falcaria vulgaris in diabetic male mice. Arch Biol Sci. 2018;70(4):655-64.


Keywords


Falcaria vulgaris; aqueous extract; hypoglycemic activity; nephroprotective activity; streptozotocin

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