TY - JOUR AU - Mitrović, Marko B. AU - Tatalović, Nikola R. AU - Nikolić-Kokić, Aleksandra L. AU - Ciraj-Bjelac, Olivera F. AU - Krstić, Nikola E. AU - Oreščanin-Dušić, Zorana S. AU - Krstić, Dragana Ž. AU - Jovanović, Zoran M. AU - Blagojević, Duško P. AU - Lazarević-Macanović, Mirjana V. PY - 2018/12/04 Y2 - 2024/03/28 TI - Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles JF - Archives of Biological Sciences JA - Arch Biol Sci VL - 70 IS - 4 SE - Articles DO - UR - https://www.serbiosoc.org.rs/arch/index.php/abs/article/view/2841 SP - 675-680 AB - <div><p><strong>Paper description:</strong></p><ul><li>There is no literature data on the influence of diagnostic doses of x-radiation during computed tomography (CT) on the oxidative status in testicles.</li><li>Our results showed that CT provoked a response at the level of antioxidant enzymes in rabbit testicles which was time- and dose-dependent, with a dose threshold of about 29.2 mGy, and predominantly under the influence of the applied current.</li><li>Our results present novel information about the influence of CT on the cellular antioxidant process.</li></ul><p><strong>Abstract: </strong>In recent years, computed tomography (CT) has become very common in veterinary medicine. It is well known that testicles are organs with high radiosensitivity and their function can be impaired even after exposure to low radiation doses. In this work, we calculated the absorbed radiation doses after CT was performed with different voltage/current levels and correlated it with the activity of antioxidant enzymes in rabbit testicles. Two hours after CT, the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were increased in the testicles of animals that received an absorbed dose of 29.2 mGy. The same changes, along with elevated glutathione reductase (GR) activity, were observed after 7 days in animals that received the highest absorbed dose (46.3 mGy). It would appear that absorbed doses above 27.8 mGy provoked the antioxidant reaction but the time scale of the reaction was dose-dependent. Examination of the obtained results revealed that the main denominator of CT influence was a higher current. Our results suggest that CT influences the antioxidant status in rabbit testicles. The changes in antioxidant enzyme activities were dose- and time-dependent and influenced by the applied current.</p><p><a href="https://doi.org/10.2298/ABS180413029M">https://doi.org/10.2298/ABS180413029M</a></p><p><strong>Received:</strong> April 13, 2018; <strong>Revised:</strong> May 23, 2018; <strong>Accepted:</strong> June 12, 2018; <strong>Published online:</strong> June 15, 2018</p><p><strong>How to cite this article: </strong>Mitrović MB, Tatalović NR, Nikolić-Kokić AL, Ciraj-Bjelac OF, Krstić NE, Oreščanin-Dušić ZS, Krstić DŽ, Jovanović ZM, Blagojević DP, Lazarević-Macanović MV. Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles. Arch Biol Sci. 2018;70(4):675-80.</p></div> ER -