TY - JOUR AU - Li, Xinying AU - Li, Jingmei AU - Yang, Jiao PY - 2019/10/23 Y2 - 2024/03/29 TI - Liprin-β1 is upregulated in human hepatocellular carcinoma and is associated with advanced tumor stage JF - Archives of Biological Sciences JA - Arch Biol Sci VL - 71 IS - 3 SE - Articles DO - UR - https://www.serbiosoc.org.rs/arch/index.php/abs/article/view/3876 SP - 469-474 AB - <div><p><strong>Paper description: </strong></p><ul><li>Dysregulation of liprin-β1 has been implicated in several types of human cancers. However, the expression of liprin-β1 and its clinicopathologic significance in human hepatocellular carcinoma remains elusive.</li><li>Protein expression of liprin-β1 in hepatocellular carcinoma and cholangiocellular carcinoma was evaluated by immunohistochemistry, and its clinical relevance was assessed. Liprin-β1 was elevated in hepatocellular carcinoma and was related to advanced tumour stage.</li><li>Our findings provide a rationale that liprin-β1 may serve as a potential biomarker for human hepatocellular carcinoma.</li></ul><br /><p><strong>Abstract: </strong>Liprin-β1 is one of the broadly-expressed liprin family members. Dysregulation of liprin-β1 has been implicated in several types of human cancers. However, the expression of liprin-β1 and its clinicopathological significance in human hepatocellular carcinoma (HCC) remains elusive. We evaluated the protein expression of liprin-β1 in HCC and non-tumor liver tissues by immunohistochemistry, and investigated the relationship between liprin-β1 expression and the clinicopathological attributes of HCC. We found that liprin-β1 expression was significantly higher in HCC than in non-tumor liver tissues. Further analysis showed that higher levels of liprin-β1 in HCC were significantly associated with the advanced clinical stage. Interestingly, liprin-β1 was not detected in cholangiocellular carcinoma specimens. These findings suggest that an elevated expression of liprin-β1 may be involved in HCC progression, providing the rationale that upregulation of liprin-β1 may serve as a novel biomarker for human HCC.</p><p><a href="https://doi.org/10.2298/ABS190116029L">https://doi.org/10.2298/ABS190116029L</a></p><div><p><strong>Received:</strong> January 16, 2019; <strong>Revised:</strong> April 3, 2019; <strong>Accepted:</strong> April 25, 2019; <strong>Published online:</strong> May 10, 2019</p><p><strong>How to cite this article:</strong> Li X, Li J, Yang J. Liprin-β1 is up regulated in human hepatocellular carcinoma and is associated with advanced tumor stage. Arch Biol Sci. 2019;71(3):469-74.</p></div></div> ER -