Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo

Gökhan Pektaş, Suzan Demir Pektaş, Aynure Öztekin, Coşkun Öztekin, Salim Neşelioğlu, Özcan Erel, Gökhan Sadi


Paper description:

  • Changes in dynamic thiol/disulfide homeostasis in generalized vitiligo was confirmed.
  • Native and total thiol contents were significantly lower in vitiligo patients.
  • Disulfide/native thiol and disulfide/total thiol ratios were higher in vitiligo patients.
  • Thiol/disulfide homeostasis was shifted toward disulfide formation.
  • Progressivity of the disease strongly regulated the thiol/disulfide homeostasis.

Abstract: Vitiligo is a multifactorial disorder commonly associated with hypo-/depigmentation in the skin and may influence both children and adults psychologically because of the notable leopard-skin-like appearance. This study was designed to investigate the thiol/disulfide homeostasis in patients with generalized vitiligo and to determine its relationship with some of the demographical characteristics. Seventy-six generalized vitiligo patients and 67 healthy individuals were included in the study. Blood serum native thiol, disulfide and total thiol concentrations, together with some hematological parameters, were determined. Results demonstrated that native and total thiol contents, and their ratios, were significantly lower in vitiligo patients. Disulfide/native thiol and disulfide/total thiol ratios were significantly higher in the patient group. Progressivity of the disease strongly regulated the thiol/disulfide homeostasis in such a way that active vitiligo patients had reduced native and total thiol levels but increased disulfide/native thiol and disulfide/total thiol ratios. Moreover, there was a statistically significant negative correlation between both duration of the vitiligo and native and total thiol contents. As these results clearly demonstrated that thiol/disulfide homeostasis was shifted toward disulfide formation in patients with generalized vitiligo, determining the dynamic nature of thiol/disulfide homeostasis can be used to monitor disease progression.


Received: October 3, 2018; Revised: October 8, 2018; Accepted: October 9, 2018; Published online: October 10, 2018

How to cite this article: Pektaş G, Pektaş SD, Öztekin A, Öztekin C, Neşelioğlu S, Erel Ö, Sadi G. Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo. Arch Biol Sci. 2019;71(1):55-62.


generalized vitiligo; native thiol; disulfide; total thiol; homeostasis

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