Antidiabetic, antioxidant, and therapeutic effects of Salvia balansae leaf and stem extracts on sexual function in diabetic male rats

Authors

  • Sendous W. Souidi Laboratory of sciences and technics of animal production, Faculty of Natural and Life Sciences (LSTAP), University Abdelhamid Ibn Badis of Mostaganem, 27000, Mostaganem, Algeria https://orcid.org/0000-0003-2880-5022
  • Mansouria Belhocine Laboratory of sciences and technics of animal production, Faculty of Natural and Life Sciences (LSTAP), University Abdelhamid Ibn Badis of Mostaganem, 27000, Mostaganem, Algeria https://orcid.org/0000-0002-3783-7651
  • Ines Feknous Food Technology and Nutrition Laboratory (LTAN), University Abdelhamid Ibn Badis of Mostaganem, 27000, Mostaganem, Algeria https://orcid.org/0000-0003-2040-7417
  • Chawki Bensouici Biotechnology Research Center (CRBT), Ali Mendjeli New Town UV 03, Constantine 25000, Algeria https://orcid.org/0000-0003-4612-4642
  • Tayeb Sitayeb Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of Plants (LBPBVP), Faculty of Natural and Life Sciences, Department of Biology, University Dr. Moulay Tahar, 20000, Saida, Algeria https://orcid.org/0000-0001-8906-8842
  • Abdelkader A. Dahou Laboratory of sciences and technics of animal production, Faculty of Natural and Life Sciences (LSTAP), University Abdelhamid Ibn Badis of Mostaganem, 27000, Mostaganem, Algeria https://orcid.org/0000-0001-6640-3169

DOI:

https://doi.org/10.2298/ABS241218041S

Keywords:

Salvia balansae Noë ex Coss, antioxidant, acute toxicity, aphrodisiac, antihyperglycemic

Abstract

Paper description:

  • Diabetes mellitus adversely impacts male sexual function. Natural antioxidants found in sage have shown therapeutic potential in mitigating diabetes-related dysfunctions.
  • balansae leaf and stem extracts were prepared using decoction methods. The extracts were analyzed for in vitro antioxidant capacity, total polyphenol, and flavonoid content. Streptozotocin-induced diabetic rats were treated orally with these extracts and data were collected on acute toxicity, glycemic levels, sexual behavior parameters, and serum testosterone levels.
  • The extracts improved glycemic control, sexual performance, and testosterone levels, highlighting their aphrodisiac potential.
  • balansae offers safe natural therapy with anti-hyperglycemic and aphrodisiac effects for managing diabetes-related sexual dysfunction.

Abstract: This study investigates the in vitro antioxidant and antidiabetic effects, and in vivo the pro-sexual activities of aqueous extracts from Salvia balansae leaves (LAE) and stems (SAE) in streptozotocin (STZ)-induced diabetic male rats. The total polyphenol and flavonoid contents, as well as the antioxidant activity of the extracts, were assessed using the DPPH radical scavenging and FRAP assays. Following the induction of diabetes by intraperitoneal injection of STZ (40 mg/kg), diabetic rats received 200 mg/kg of LAE/SAE. Acute oral toxicity, glycemic levels, sexual behavior parameters, and serum testosterone levels were assessed. S. balansae extracts exhibited high levels of total polyphenols and flavonoids, reflecting an antioxidant capacity. Acute toxicity tests confirmed a high safety margin, with no observed toxicity at doses up to 2 g/kg. In diabetic rats, LAE and SAE administration reduced hyperglycemia and enhanced sexual function, as evidenced by increased male-female interaction frequency, decreased latency times, and elevated serum testosterone levels, pointing to an aphrodisiac effect. This work demonstrates the therapeutic potential of S. balansae leaf and stem extracts in improving reproductive function in diabetic rats, potentially through its antioxidant, antihyperglycemic and aphrodisiac properties.

Keywords: Salvia balansae Noë ex Coss, antioxidant, acute toxicity, aphrodisiac, antihyperglycemic.

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Published

2025-04-29

How to Cite

1.
Souidi SW, Belhocine M, Feknous I, Bensouici C, Sitayeb T, Dahou AA. Antidiabetic, antioxidant, and therapeutic effects of Salvia balansae leaf and stem extracts on sexual function in diabetic male rats. Arch Biol Sci [Internet]. 2025Apr.29 [cited 2025May17];77(1):27-36. Available from: https://www.serbiosoc.org.rs/arch/index.php/abs/article/view/10594

Issue

Vol. 77 No. 1 (2025)

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Articles

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Copyright (c) 2025 Sendous Wadjila SOUIDI, Mansouria Belhocine, Ines Feknous, Chawki Bensuici, Tayeb Sitayeb, Abdelkader A. Dahou

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