Korean red ginseng extracts alleviate skin damage in heat-stimulated skin cells by suppressing NF-κB activation

Authors

  • Jeeyoung Kim 1Research and Development Center, Durae Corporation, Anyang Trade Center 14F, 161, Simin-daero, Dongan-gu, Anyang, Gyeonggi-do, 14048, Republic of Korea https://orcid.org/0000-0001-5025-1615
  • Weon Jeong Bang 1Research and Development Center, Durae Corporation, Anyang Trade Center 14F, 161, Simin-daero, Dongan-gu, Anyang, Gyeonggi-do, 14048, Republic of Korea https://orcid.org/0000-0003-4857-1489
  • Yung Hyup Joo 1Research and Development Center, Durae Corporation, Anyang Trade Center 14F, 161, Simin-daero, Dongan-gu, Anyang, Gyeonggi-do, 14048, Republic of Korea https://orcid.org/0000-0001-9677-792X
  • Sung Hyun Lee 1Research and Development Center, Durae Corporation, Anyang Trade Center 14F, 161, Simin-daero, Dongan-gu, Anyang, Gyeonggi-do, 14048, Republic of Korea https://orcid.org/0000-0002-1928-7369
  • Chang-Seok Lee 1. Department of Senior Healthcare, Eulji University, Sujeong-gu, Seongnam, Gyeonggi-do 13135, Republic of Korea; 2. Cosmetic Science Major, Eulji University, Sujeong-gu, Seongnam, Gyeonggi-do 13135, Republic of Korea https://orcid.org/0000-0002-4814-5685

Keywords:

fibroblasts, heat stimulation, keratinocytes, red ginseng, skin damage

Abstract

Paper description:

  • Red ginseng extract (RG) contains ginsenosides, gintonins, and polypeptides, and exhibits anti-aging, immunomodulatory, and anti-inflammatory properties.
  • In vitro studies examined the recovery effects of RG on skin damage caused by heat-induced barrier disruption, aging, and inflammation.
  • RG alleviated skin barrier damage. Nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways were activated by heat stimulation, but only NF-κB activation was suppressed by RG treatment.
  • RG restores and alleviates skin damage.

Abstract: This study explored the impact of heat stimulation on skin barrier damage, aging, and inflammatory responses by analyzing gene and protein-level changes. Additionally, it examined the restorative effects and regulatory mechanisms of red ginseng (RG) extract. The results demonstrated that heat stimulation decreased mRNA expression of the skin barrier markers, aquaporin 3 (AQP3), ceramide synthase 3 (CerS3), and occludin (OCL), while increasing the expression of matrix metalloproteinases (MMP)-1, MMP-2, and MMP-3, and proinflammatory factors such as interleukins IL-6 and IL-8, which are associated with skin damage. RG treatment modulated the expression of disrupted skin barrier markers (AQP3, CerS3, OCL), aging markers (MMP-1, -2, -3), and inflammatory factors (IL-6, IL-8), confirming the recovery-promoting effects against heat-induced skin damage. Mechanistic analysis revealed that both nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways were activated by heat stimulation, with NF-κB activation suppressed by RG treatment. In conclusion, RG demonstrated the ability to restore skin integrity and alleviate damage.

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Published

2025-04-29

How to Cite

1.
Kim J, Bang WJ, Joo YH, Lee SH, Lee C-S. Korean red ginseng extracts alleviate skin damage in heat-stimulated skin cells by suppressing NF-κB activation. Arch Biol Sci [Internet]. 2025Apr.29 [cited 2025May17];77(1):83-92. Available from: https://www.serbiosoc.org.rs/arch/index.php/abs/article/view/10777

Issue

Vol. 77 No. 1 (2025)

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Articles

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Copyright (c) 2025 Jeeyoung kim, Weon Jeong Bang, Yung Hyup Joo, Sung Hyun lee, changseok lee

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