Therapeutic effects of polysaccharides extracted from Porphyra yezoensis in rats with cerebral ischemia/reperfusion injury


  • Changjiang Sun Department of Pharmacy, The Second People’s Hospital of Nantong, Nantong 226002, Jiangsu
  • Feng Wu Department of Pharmacology, Nantong University School of Medicine, Nantong 226001
  • Dandan Chen Department of Pharmacy, The Second People’s Hospital of Nantong, Nantong 226002, Jiangsu
  • Jianbin Ge Department of Pharmacy, The Second People’s Hospital of Nantong, Nantong 226002, Jiangsu


Porphyra yezoensis, neurological deficit, cerebral infarct, oxidative stress


The polysaccharides of Porphyra yezoensis (PPY), porphyrans, are recognized as the major active components as they have several biological properties. This study was performed to assess the effect of PPY administration against cerebral ischemia-reperfusion injury (IRI). Thirty-two adult Sprague-Dawley (SD) rats were chosen and divided into 4 groups as follows: group I – rats received only saline; group II – subjected to middle cerebral artery occlusion (MCAO) for 60 min followed by 24 h of reperfusion (IRI-induced); group III – pretreated with PPY (100 mg/kg) for 7 days, followed by IRI induction; group IV – treated with PPY (100 mg/kg) for 7 days without IRI induction. All the data were analyzed by Dunnett’s (multiple comparisons) test using SPSS software. Pretreatment with PPY significantly (p<0.01) lowered the neurological deficit and cerebral infarct volume in comparison with IRI-induced rats. A pronounced (p<0.01) increase in the levels of antioxidant components (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH)) was observed in PPY-supplemented rats. Also, the proinflammatory markers: interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and the nuclear factor-kappa B protein, subunit p65 (NF-κB p65) were substantially (p<0.01) suppressed in PPY-administered rats. Moreover, the protein levels of TNF-α and NF-κB p65 were considerably (p<0.01) downregulated upon pretreatment with PPY. Our data suggest that PPY could exhibit neuroprotective activity by attenuating oxidative stress and the inflammatory response.

Received: June 21, 2017; Revised: October 8, 2017; Accepted: October 8, 2017; Published online: October 16, 2017

How to cite this article: Sun C, Wu F, Chen D, Ge J. Therapeutic effects of polysaccharides extracted from Porphyra yezoensis in rats with cerebral ischemia/reperfusion injury. Arch Biol Sci. 2018;70(2):233-9.


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How to Cite

Sun C, Wu F, Chen D, Ge J. Therapeutic effects of polysaccharides extracted from Porphyra yezoensis in rats with cerebral ischemia/reperfusion injury. Arch Biol Sci [Internet]. 2018Apr.27 [cited 2022Sep.29];70(2):233-9. Available from: