Protective effect of the Rubus chingii Hu. fruit extract on ultraviolet B-induced photoaging via suppression of mitogen-activated protein kinases (MAPKs) in vitro

Authors

  • Jie-Mei She Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237 http://orcid.org/0000-0003-3385-4857
  • Hui-Hui Yuan 1. Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237; 2. Institute of Applied Chemistry, East China University of Science and Technology, Shanghai 200237 http://orcid.org/0000-0002-6492-3686
  • Jin Zhang Shanghai Putuo Hospital of Traditional Chinese Medicine, Shanghai 200062 http://orcid.org/0000-0003-0962-7005
  • Zhao-Nian Si Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237 http://orcid.org/0000-0001-9116-8615
  • Min-Bo Lan 1. Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237; 2. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237 http://orcid.org/0000-0002-4247-0006

Keywords:

Rubus chingii Hu., antioxidant activity, anti-photoaging, reactive oxygen species (ROS), mitogen-activated protein kinase (MAPK) signaling pathway

Abstract

Paper description:

  • Rubus chingii Hu possesses antioxidant, anti-inflammatory and anti-aging activities.
  • The ethanol extract of the fruit (E-EA) demonstrated significant anti-photoaging properties in UVB-induced human fibroblast (HFF-1) cells, observed as a decrease in levels of reactive oxygen species (ROS), inhibition of matrix metallopeptidase 1 (MMP-1) production, and promotion of type-I procollagen production via suppression of the mitogen-activated protein kinase (MAPK) signaling pathway.
  • E-EA is suggested as a potential anti-photoaging agent for the protection of skin from UVB damage.

Abstract: Rubus chingii Hu. is an important traditional Chinese medicine with a beneficial effect on the kidney. Traditional Chinese medicine theory believes that supporting the kidney has a key role in anti-aging. To the best of our knowledge, the anti-photoaging activity of Rubus chingii Hu. has not been investigated. We investigated the anti-photoaging effects and the underlying mechanism of the ethyl acetate fraction of Rubus chingii Hu. fruit ethanol extract (E-EA) in UVB-induced human fibroblasts (HFF-1). Our results show that E-EA (10-40 μg/mL) displayed preventive and therapeutic effects on UVB-induced cytotoxicity in HFF-1 cells. E-EA also presented significant anti-photoaging properties in UVB-induced HFF-1 cells by decreasing the levels of reactive oxygen species (ROS), inhibiting matrix metallopeptidase 1 (MMP-1) production and promoting type-I procollagen production via suppression of the mitogen-activated protein kinase (MAPK) signaling pathway. These results suggested that E-EA might be a promising anti-photoaging agent to protect the skin from UVB damage, with a potential application in cosmetics.

https://doi.org/10.2298/ABS190321038S

Received: March 21, 2019; Revised: May 3, 2019; Accepted: June 3, 2019; Published online: July 7, 2019

How to cite this article: She J, Yuan H, Zhang J, Si Z, Lan M. Protective effect of the Rubus chingii Hu. fruit extract on ultraviolet B-induced photoaging via suppression of mitogen-activated protein kinases (MAPKs) in vitro. Arch Biol Sci. 2019;71(3):541-50.

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Published

2019-10-23

How to Cite

1.
She J-M, Yuan H-H, Zhang J, Si Z-N, Lan M-B. Protective effect of the Rubus chingii Hu. fruit extract on ultraviolet B-induced photoaging via suppression of mitogen-activated protein kinases (MAPKs) in vitro. Arch Biol Sci [Internet]. 2019Oct.23 [cited 2022Aug.9];71(3):541-50. Available from: https://www.serbiosoc.org.rs/arch/index.php/abs/article/view/4117

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