rs2682818/MiR-618 is a novel marker associated with increased risk of breast cancer in the Iranian population

Authors

  • Atefeh Najafian-Najafabady Division of Genetics, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, Islamic Republic of Iran
  • Nasim Ebrahimi Division of Genetics, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, Islamic Republic of Iran
  • Sadeq Vallian Division of Genetics, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, Islamic Republic of Iran https://orcid.org/0000-0002-5151-5923

DOI:

https://doi.org/10.2298/ABS210808039N

Keywords:

breast cancer, miR-618, polymorphism, ARMS-PCR, Iranian population

Abstract

Paper description:

  • micro-RNA-618 (miR-618) plays a major role in a variety of tumors, including breast cancer.
  • rs2682818/miR-618 polymorphism in breast cancer patients and healthy individuals was genotyped to examine the association between this polymorphism and breast cancer prevalence.
  • correlation between rs2682818/miR-618 and the risk of breast cancer is statistically significant (OR=2.97, P=0.0003).
  • rs2682818/miR-618 could be considered as an important marker associated with the risk of breast cancer

Abstract: The presence of single nucleotide variations in the coding region of micro-RNA (miRNA)-encoding genes plays a significant role in the expression and function of these molecules in oncogenesis and cancer. The association of rs2682818 in miR-618 with increased risk of breast cancer was investigated in the Iranian population. rs2682818/miR-618 was genotyped using amplification-refractory mutation system PCR (ARMS-PCR) in 200 healthy individuals and patients with breast cancer. The data revealed the presence of Hardy-Weinberg equilibrium (HWE) for this marker. The frequency of alleles C and A was 70% and 30%, respectively, in healthy individuals; the frequency of alleles C and A was 44% and 56%, respectively, in patients with breast cancer. Analysis of odd ratios showed that the rs2682818/miR-618 polymorphism is associated with increased probability of breast cancer and is statistically significant (OR=2.97, P=0.0003). The data suggest that rs2682818/miR-618 could be considered a novel marker of increased risk of breast cancer.

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Published

2021-12-15

How to Cite

1.
Najafian-Najafabady A, Ebrahimi N, Vallian S. rs2682818/MiR-618 is a novel marker associated with increased risk of breast cancer in the Iranian population. Arch Biol Sci [Internet]. 2021Dec.15 [cited 2022Sep.28];73(4):457-63. Available from: https://www.serbiosoc.org.rs/arch/index.php/abs/article/view/6896

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